Some of this is going to be US-centric.
Relative powerlessness to do anything about all other items on this list
Global warming (expandable!)
I’m a citizen of a country that tortures people and makes them disappear
We’re all “good Germans” (see above two, several from below)
Erosion of civil rights (see: war on drugs, war on terror)
Non-global warming environmental issues
We’re not going to get onto clean energy sources before we can’t use dirty ones/there aren’t dirty ones left so the last two humans face off with clubs over a preserved bottle of Penzoil in a couple decades.
Media consolidation and lack of discussion of topics on this list
Politicization/Evangelism of military
Politicization of other government services (TSA)
Quality of educational system (particularly race/class discrimination)
Societal inability to find reasonable compromises (see: war on drugs, erosion of civil rights, also: health care/copyright laws)
… and so on
I don’t know, looking that over, none of it seems particularly unreasonable to be anxious about.